What is deCODE MI™?
deCODE MI™ is a reference laboratory DNA test for assessing an inherited risk factor for MI. The test detects versions of markers called SNPs (single nucleotide polymorphisms) – a one letter variation in the sequence of the genome, more specifically on chromosome 9p21 – that deCODE has linked to increased risk of coronary heart disease and MI.
deCODE MI™ is a genetic test for increased risk for myocardial infarction (MI or heart attack), especially MI occurring at an early age, or before the age of 50 for men and 60 for women. It is a reference laboratory test which detects single base changes or SNPs in the CDKN2A/2B gene region on chromosome 9. deCODE genetics has reported, based on studies of thousands of patients, that individuals who are positive for this test have 1.6 fold the risk of developing early onset MI compared to the general population. It also appears to be a risk factor for MI in general, carrying with it a 1.3 fold the general population risk regardless of age. About 20% of the general population are positive for this test. This has been confirmed in US and other European populations. Healthy living and targeted treatments of risk contributing conditions such as hypertension, diabetes and elevated blood lipids are the cornerstones of modern prevention of cardiovascular diseases, including coronary artery di
deCODE MI™ is a reference laboratory DNA test for assessing an inherited risk factor for MI. The test detects versions of markers called SNPs (single nucleotide polymorphisms) – a one letter variation in the sequence of the genome, more specifically on chromosome 9p21 – that deCODE has linked to increased risk of coronary heart disease and MI. The risk variants are the “G” allele of SNP rs10757278 and the “C” allele in SNP rs1333049 located in the vicinity of the tumor suppressor genes CDKN2A and CDKN2B on chromosome 9p21. These proteins play a critical role in regulating cell proliferation, cell aging and the associated degeneration, and the programmed cell death of many cell types. These are all important features of atherogenesis or plaque formation in vessels, the underlying cause of coronary heart disease and MI. Despite their vicinity to theses genes, the mechanism whereby the genetic variants exert their effects in the pathogenesis of MI remains to be elucidated. What is this te
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