What is CPP-ACP, and how does it work?
CPP-ACP is the acronym for a complex of casein phosphopeptides and amorphous calcium phosphate. Casein phosphopeptides (CPP) are a group of peptides derived from casein, part of the protein that occurs naturally in milk. The CPP are thought to be responsible for the high bioavailability of calcium from milk and other dairy products. The CPP containing the amino acid cluster sequence -Ser(P)-Ser(P)-Ser(P)-Glu-Glu have the ability to bind and stabilize calcium and phosphate in solution, as well as bind to dental plaque and tooth enamel. Calcium phosphate is normally insoluble, ie. forms a crystalline structure at neutral pH. However, the CPP keep the calcium and phosphate in an amorphous, non-crystalline state. In this amorphous state calcium and phosphate ions can enter the tooth enamel. The high concentration of calcium and phosphate ions in dental plaque following exposure to CPP-ACP have been extensively researched and proven to reduce the risk of enamel demineralization and promote
