What is considered a significant change to a project that would require IACUC review?
• in the objectives of a study • from non survival to survival surgery; • resulting in greater discomfort or in a greater degree of invasiveness; • in the species or in approximate number of animals used; • in Principal Investigator; • in anesthetic agent(s) or the use or withholding of analgesics; • in the method of euthanasia; and • in the duration, frequency, or number of procedures performed on an animal. [A4, A7, A13] Changes in personnel other than the Principal Investigator need not be considered significant provided that an appropriate administrative review mechanism is in place to ensure that all such personnel are appropriately identified, adequately trained and qualified, enrolled in applicable occupational health and safety programs, and meet other criteria as required by the IACUC. See NIH Guide for Grants and Contracts NOT OD-03-046. The IACUC has some discretion to define what it considers a significant change, or to establish a mechanism for determining significance on
• in the objectives of a study • from non survival to survival surgery; • resulting in greater discomfort or in a greater degree of invasiveness; • in the species or in approximate number of animals used; • in Principal Investigator; • in anesthetic agent(s) or the use or withholding of analgesics; • in the method of euthanasia; and • in the duration, frequency, or number of procedures performed on an animal. [A4, A7] Changes in personnel other than the Principal Investigator need not be considered significant provided that an appropriate administrative review mechanism is in place to ensure that all such personnel are appropriately identified, adequately trained and qualified, enrolled in applicable occupational health and safety programs, and meet other criteria as required by the IACUC. See NIH Guide for Grants and Contracts NOT OD-03-046. The IACUC has some discretion to define what it considers a significant change, or to establish a mechanism for determining significance on a cas
Examples of changes considered to be significant include, but are not limited to, changes: • in the objectives of a study • from non survival to survival surgery; • resulting in greater discomfort or in a greater degree of invasiveness; • in the species or in approximate number of animals used; • in Principal Investigator; • in anesthetic agent(s) or the use or withholding of analgesics; • in the method of euthanasia; and • in the duration, frequency, or number of procedures performed on an animal. [A4, A7, A13]Changes in personnel other than the Principal Investigator need not be considered significant provided that an appropriate administrative review mechanism is in place to ensure that all such personnel are appropriately identified, adequately trained and qualified, enrolled in applicable occupational health and safety programs, and meet other criteria as required by the IACUC. See NIH Guide for Grants and Contracts NOT OD-03-046. The IACUC has some discretion to define what it co
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