What is Centronuclear Myopathy Disease “CNM”?
Centronuclear Myopathy (CNM) is an inherited autosomal recessive disorder and is characterized by muscle weakness and exercise intolerance. DDC Veterinary is offering DNA Testing for Centronuclear Myopathy. Labrador Breeders have an accurate, convenient, and affordable tool to help them avoid producing CNM affected offspring and significantly reduce the gene frequency in future generations. There are 3 possible genotypes reported for Centronuclear Myopathy: • CLEAR (those having 2 copies of the normal allele and appear to be normal). • CARRIER (those having 1 copy of the normal allele and 1 copy of the mutation but appear to be normal). • AFFECTED (those having 2 copies of the mutation and will likely begin to show fatigue, muscle weakness and exercise intolerance after a few months of age. It is important to note that although carriers will not show clinical signs for the disease, if used for breeding, they will pass on the mutation 50% of the time, therefore a carrier x carrier matin
