What is Cationic Gold?
Cationic gold allows highly sensitive and discrete microscopical studies of anionic (i.e. negative) sites in cells and tissues. The gold conjugate is made by careful coupling of poly-L-lysine, a highly positive amino acid chain. A simple of step incubation of sections with the diluted Cationic Gold conjugates reveals subcellular sites having net negativity charge. The charge distribution can be seen at a range of magnifications by using cationic Gold of different particle sizes. (Reference: 1. Bush MS and Allt G (1990) “Blood nerve barrier distribution of anionic sites on the endothelial plasma membrane and basal lamina” Brian Res. 535.
