What is atherogenesis and how is it influenced by insulin resistance?
Atherogenesis is the formation of atheroma-lipid deposits in the intima of the arteries. Atheroma produce a swelling on the endothelial surface, which is a characteristic of atherosclerosis. In the prediabetic patient, the macrovascular system tends to be in a highly atherogenic state. The results of several recent studies of diabetes and CV disease implicate increased insulin resistance as the culprit in the enhanced risk of the prediabetic state.
