What is antinuclear antibody (ANA)?
Antibodies are substances that are produced by the immune system of the body to fight the germs causing infection. Sometimes there is abnormal production of antibodies (auto-antibody) that attack the body’s own body systems and tissues leading to autoimmune diseases such as systemic lupus erythematosus (SLE), Rheumatoid Arthritis (RA), scleroderma, Sjogren’s syndrome etc. Antinuclear antibodies (ANA) are unusual antibodies that are directed against the structures within the nucleus of the cells. Presence of ANA indicates the presence of autoimmune disease.