What is angiogenesis and what role is it playing in cancer treatment for sarcoma patients?
Angiogenesis literally means growing of new blood vessels. No tissue in the body can live further than 200 microns from a blood vessel as this is the diffusion capacity of oxygen which is necessary to sustain cellular metabolism. For tumors to grow (or for their metastasis to grow) they must grow their own new blood vessels. This is done through elaboration of compounds such as VEGF (vascular endothelial growth factor). Where angiosarcomas and cancer become linked in potential treatment is through compounds that do the opposite and inhibit new blood vessel growth such as angiostatin and endostatin. These are the subject of on-going clinical trials at this time. Is there any other advice you would like to share with families affected by cardiac angiosarcoma? Cardiac sarcomas are complex and unusual diseases. Their treatment should optimally be done in institutions with an interest in and large volume of cancer cases and by cardiac surgeons with experience in this area. Because of the ra
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