What is angiogenesis and how does it play a role in cancer treatment?
An ESUN Article Dr. Mary Louise Keohan Blood vessels are the tubes through which the blood circulates in the body. They include an interconnected network of arteries, arterioles, capillaries, venules, and veins. Angiogenesis (an-gee-o-gen-eh-sis) is a multistep biological process that stimulates the development of new blood vessels and tumor metastases while maintaining existing blood vessels. Endogenous positive and negative regulating factors control the process. “Endogenous” refers to something produced inside an organism or cell; whereas as “exogenous” is the opposite, i.e., produced external to the organism or cell. Tumor angiogenesis is the growth of blood vessels between a tumor and its surrounding tissue. New blood vessels help the tumor to grow by feeding the cancer cells with essential nutrients and oxygen. Anti-angiogenesis agents or “inhibitors” are substances which prevent or destabilize the angiogenic process in a number of different ways (e.g., inhibition of endothelial
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