What is Agilents new HPLC-Chip technology?
Agilent’s HPLC-Chip is the first microfluidic chip-based device that can carry out nanoflow high performance liquid chromatography (HPLC). The centerpiece of Agilent’s new HPLC-Chip technology is a reusable microfluidic polymer chip. Smaller than a credit card, the HPLC-chip seamlessly integrates the sample enrichment and separation -columns of a nanoflow LC system with the intricate connections and spray tip used in electrospray mass spectrometry directly on the polymer chip. The technology eliminates 50% of the traditional fittings and connections typically required in an nanoflow LC/MS system, dramatically reducing the possibility of leaks and dead volumes and significantly improving ease of use, sensitivity, productivity and reliability during analysis. The second component of the HPLC-Chip technology is the HPLC-Chip/MS interface. A chip is inserted into the interface, which mounts on an Agilent mass spectrometer. The design configuration guarantees that the electrospray tip is in
