What is Aggressive Systemic Mastocytosis (ASM)?
Aggressive systemic mastocytosis (ASM) is a myeloproliferative disorder characterized by the abnormal growth, proliferation, and accumulation of mast cells in one or more organs that can, in some cases, lead to organ failure. There is usually severe involvement of the bone marrow, liver, spleen, and lymphatic system. Mast cells are produced in the bone marrow and contain chemical mediators, like histamine, that are released in response to inflammatory and allergenic events.
