What is abnormal about the anatomy of the digestive system in Crohns Disease?
Deepakmr is right, however, those changes occur later in the pathophysiology of Chrohn’s disease. The disease starts with crypt inflammations and abscesses that progress to tiny focal aphthoid ulcers along the intestinal lining. These lesions eventually coalesce into longitudinal and transverse ulcers with intervening mucosal edema, creating the characteristic cobblestoned appearance under the microscope. The spread of this inflammation and thickening of the bowel wall is what then causes the blockages and the gastrointestinal symptoms characteristic of the disease.
