What Is a Useful Definition of Ischemic Nephropathy?
The definition of ‘ischemic nephropathy’ is unclear. We will use ‘impairment of renal function beyond occlusive disease of the main renal arteries’ [12]. However, deterioration of renal function in the presence of RAS may not reflect ‘ischemia’. Under normal conditions blood flow to the kidney is far in excess of metabolic needs [14]. Thus, moderate absolute reductions in blood flow as in RAS may not be the sole or even a major contributor to reduced renal function. Furthermore, given the ability of the kidney to compensate with an increased single nephron GFR, even the loss of a single kidney from reduced or occluded vascular supply should not adversely affect renal function in the absence of additional insults. Thus, the view that reduction in renal blood flow directly results in ischemic damage is overly simplistic. Since the prevalence of RAS depends on definition and methodology, the true prevalence is not known. Given the increased survival of patients with cardiac disease and th
The definition of ‘ischemic nephropathy’ is unclear. We will use ‘impairment of renal function beyond occlusive disease of the main renal arteries’ [12]. However, deterioration of renal function in the presence of RAS may not reflect ‘ischemia’. Under normal conditions blood flow to the kidney is far in excess of metabolic needs [14]. Thus, moderate absolute reductions in blood flow as in RAS may not be the sole or even a major contributor to reduced renal function. Furthermore, given the ability of the kidney to compensate with an increased single nephron GFR, even the loss of a single kidney from reduced or occluded vascular supply should not adversely affect renal function in the absence of additional insults. Thus, the view that reduction in renal blood flow directly results in ischemic damage is overly simplistic. Since the prevalence of RAS depends on definition and methodology, the true prevalence is not known. Given the increased survival of patients with cardiac disease and th
Related Questions
- What is the correct definition of Free Cash Flow and is it useful to compare a companys performance from one year to the next, on the basis of Free Cash Flow and the way it changes?
- What definition of software defect is useful for measuring the efficacy of testing?
- What Is a Useful Definition of Ischemic Nephropathy?
