What is a Toxicant-Induced Loss of Tolerance (TILT)?
TILT is a two-step disease mechanism that has emerged in medicine over the past decade. Following acute exposure to a contaminant, some genetically susceptible subjects then lose tolerance for everyday exposures, which are often unrelated to the original exposure. There is strong suspicion that TILT could result in ASDs (see Environmental Exposures and ASDs: Making the Connection by Claudia S. Miller, M.D., M.S.).
