What is a Third Party Annotation (TPA) Sequence?
TPA: A database designed to capture experimental or inferential results that support submitter-provided annotation for sequence data that the submitter did not directly determine but derived from GenBank primary data. TPA records are divided into two categories: TPA:experimental: Annotation of sequence data is supported by peer-reviewed wet-lab experimental evidence. TPA:inferential: Annotation of sequence data by inference (where the source molecule or its product(s) have not been the subject of direct experimentation) TPA database records differ from GenBank and RefSeq records: GenBank: An archival database of primary nucleotide sequences that were directly sequenced by the submitter. RefSeq: A curated, non-redundant database that includes genomic DNA, transcript (RNA), and protein products, for major organisms. The sequence data are derived from GenBank primary data, and the annotation is computational, from published literature, or from domain experts. A TPA sequence is derived or
