What is a substantial drop and what do I do?
A substantial drop in WBC or ANC is defined as single or cumulative decrease in lab values from one lab to the next over the past 3 weeks. For WBC counts, a single drop is defined as a decrease of 3,000 units or more when you compare the current lab to the last lab and a cumulative drop is a decrease of a total of 3,000 units or more over all labs within the past 3 weeks. For ANC values, a single drop is defined as a decrease of 1,500 units or more when you compare the current lab to the last lab and a cumulative drop is a decrease of a total of 1,500 units or more over all labs within the past 3 weeks. Refer to Table 1 in the Clozapine Package Insert to determine actions associated with lab values. Click here for a copy.
