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What ion is responsible for firing an action potential in an excitable cell?

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What ion is responsible for firing an action potential in an excitable cell?

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Calcium ions allow vesicles (these are essentially containers of small molecules and ions in the cell) at the end of a cell body to fuse with the cell membrane and release their contents into the outside environment. In this outside environment, the released contents bind with certain receptors on a neighboring cell, which is then depolarized, generating a new action potential.

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