What information is available on the stability and compatibility of AlbuRx® when mixed with other intravenous preparations?
A. CSL Behring has not conducted any studies on the stability and compatibility of AlbuRx® when mixed with other intravenous preparations and, therefore, cannot recommend use of AlbuRx® other than as a single-product infusion. Changes in pH or osmolarity are known to have the potential to denature or modify human serum albumin. Certain chemicals, such as antibiotics, nutrients, or electrolytes in high concentration could cause albumin to aggregate in solution intended for intravenous administration. Important Safety Information The use of AlbuRx® 5 and 25 is contraindicated in patients with a history of an incompatibility reaction to albumin (human). In addition, AlbuRx® 5 may be contraindicated in patients with cardiac failure or severe anemia because of the risk of acute circulatory overload. Though very rare, non-septic incompatibility reactions including nausea, chills, fever, urticaria, headache, and hypotension following the administration of albumin-containing preparations have
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