WHAT IF THE AFP TEST RESULT IS ABNORMAL?
First, a review of all the factors that go into the formula used to calculate the result should be done to verify accuracy. Next, the levels of the substances measured are reviewed and a risk determination is made. Then, if not already done, an ultrasound exam will confirm the woman’s correct gestational age and rule out twins. If all the factors in the formula are accurate, and the test result shows the woman to be at risk for a neural tube defect, then some providers will order a second AFP test to confirm the first abnormal result. AFP testing which includes HCG and UE3 measurements — for example, the triple screen — is done only once. Further testing is very often recommended. If the woman is shown to be at increased risk for having a baby with Down Syndrome, then amniocentesis is most often offered. If the woman’s fetus is shown to be at risk for having a neural tube defect or an abdominal wall defect, then a special ultrasound examination called LEVEL 2 or “TARGETED” might be a
