What have been the latest breakthroughs in new drug research for malaria disease?
Now there is a great deal of awareness about the disease and a lot of workers from different backgrounds/fields are using the parasite as a model. The DNA sequence of Plasmodium falciparum, the most virulent form of the parasite, is available. This has given an insight into the parasites basic biology, which is very interesting, full of surprises and this will hopefully also lead to new drug molecules. In fact, many labs have now come up with new drug targets. These are essential and are obtained by studying in detail the modern parasite biology. New drug structures or as we call it new pharmacophores are obtained if a new reaction in the parasite or a new step in the parasite survival biology is defined which is caused by an enzyme and if that enzyme is hit, the parasite dies. This rational drug design approach was lacking before. The drug development process is a long one… Yes, it is a very long process and many of the molecules fall off on the way. Even if I am excited that I have
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