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What happens to the CAP /CIP ratio when the dose of vitamin D or calcium is decreased?

April 26, 2017calcium cap CIP decreased dose happens ratio vitamin d

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What happens to the CAP /CIP ratio when the dose of vitamin D or calcium is decreased?

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Faugere, et. al., have demonstrated that when calcium is increased within physiological limits in a dialysis patient, that the CAP /CIP ratio decreases. (ref. Monier-Faugere, Malluche, et. al., Kidney International, 2001; 60:1460-1468.) It has been demonstrated that administration of vitamin D seems to increase the predominant secretion of CIP (7-84 PTH) over CAP (1-84 PTH). (ref. Kazama JJ., et. al., “Hypocalcemic 7-84 PTH Fragment Level Increases with Vitamin D Treatment.” Abstract submitted for ERA-EDTA Annual Congress, July, 2002, Copenhagen, Denmark.) Moreover, it has been typically observed by SCL that when vitamin D is decreased in an ESRD patient, the CAP /CIP ratio increases. This makes sense if we consider CIP (7-84 PTH) as the parathyroid glands hormonal messenger to lower serum calcium.