What happens to radioactive iodine uptake in Graves disease?
Radioactive iodine uptake increases in Graves’ disease. Which is the best laboratory test to diagnose hyperthyroidism? Serum TSH measurement is the single most reliable test to diagnose all common forms of hyperthyroidism, particularly in an outpatient setting (Arch Intern Meal 2000; 160: 1573-5). Typically, serum concentrations are less than 0.1 mIU/l in Graves’ disease, toxic adenoma, nodular goitre, subacute and lymphocytic (silent, postpartum) thyroiditis, iodine-induced hyperthyroidism and exogenous thyroid hormone excess. To diagnose hyperthyroidism accurately, TSH assay sensitivity, the lowest reliably measured TSH concentration, must be 0.02 mlU/l or less. Some less sensitive TSH assays cannot reliably distinguish hyperthyroidism from euthyroidism. Free T4 and T3 concentrations should be measured when less sensitive TSH assays are utilized. In rare types of TSH-mediated hyperthyroidism (pituitary adenomas and selective pituitary resistance to thyroid hormone) serum TSH alone wi
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