What happens after lipoprotein lipase?
The Fatty acid Incorporation into human Adipose Tissue (FIAT), the metabolic step after the hydrolysis of plasma triglyceride (TG)-bound fatty acids (FA) by lipoprotein lipase, was studied by an in-vitro technique to investigate its role and reactions to various substrates, drug and dietary treatments in hypertriglyceridaemia (HTG). We found that FIAT was reduced, P less than 0.001, in patients with HTG and a recent myocardial infarction compared to normotriglyceridaemic (NTG) patients. Patients with very high plasma TG levels had the lowest FIAT. There were highly significant positive correlations between FIAT in several subcutaneous regions and omental fat with highest activities in the omental fat. FIAT increased approximately linearly with increasing medium FA concentrations in both NTG and HTG patients. Low values were more common in HTG. In both groups, however, the rate of fatty acid mobilizing lipolysis was significantly decreased when FA increased. FA thus seems to have import
