What groups of people are responsible for decisions at the various stages of development?
• Access and Information Group, an interdisciplinary group of scientists from DTP, makes recommendations for the initial tumor screen. This committee makes sure that each compound tested has a biological rationale and novel chemical structure. • Screening Data and Review Committee, a group of biologists and chemists from DTP, reviews the screening data from the tumor cell lines and recommends which candidate drugs should be tested in animals. • Biological Evaluation Committee (BEC), an interdisciplinary group of 15 to 25 extramural scientists, meets monthly to evaluate tumor screening and hollow fiber data. The BEC makes recommendations to halt or proceed with testing. • Drug Development Group (DDG), an interdisciplinary group of 15 to 25 NCI clinicians and scientists, meets monthly to evaluate all the in vivo data from compounds that are under serious consideration for testing in humans. This group decides whether or not to recommend a drug for human trials. • What is the usual proced
