What factors were used to determine increased risk of breast cancer for the participants aged 35 to 59?
To enroll in the study, women between 35 and 59 years of age needed to have a risk of developing breast cancer within the next five years that was equal to or greater than the average risk for 60-year-old women. This increased risk was determined in one of two ways. Women diagnosed as having lobular carcinoma in situ, a condition that is not cancer but indicates an increased chance of developing invasive breast cancer, were eligible based on that diagnosis alone. The risk for other women was determined by a computer calculation based on the following factors: • Number of first-degree relatives (mother, daughters, or sisters) who had been diagnosed as having breast cancer; • Whether a woman had any children and her age at her first delivery; • The number of times a woman had breast lumps biopsied, especially if the tissue was shown to have a condition known as atypical hyperplasia; and • The woman’s age at her first menstrual period. For example, a 35-year-old woman would have to have t
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