What ethical principles guide the IRB?
The IRB is guided by three basic principles set forth in the Belmont Report. 1) Respect for Persons: Treating subjects with dignity and autonomy while affording those with diminished autonomy with additional protections. It underlies the importance of informed consent. 2) Beneficence: An obligation to not harm subjects; to maximize benefits and minimize possible harms. 3) Justice: Fairness in the selection of research subjects; fairness in the distribution of benefits and risks.