What environmental factors that can change the shape of an enzyme?
Enzymes have an optimal pH and an optimal temperature. This means that each enzyme has a pH and a temperature that it works best in. Once that optimal pH or temperature is reached, enzyme activity drops. This is because the enzyme losses its configuration once that optimal pH or temperature is reached. If the configuration of the enzyme is lost, the enzyme will not be able to fit properly into its active site, making it useless. This also happens in a temperature or pH that is too low for enzymatic activity. Along these lines, we can see that, pH and temperature are one key regulators of enzyme activity.