What drugs will be given to children in ARROW?
Children are selected at random for one of three treatment groups. All three treatment groups include abacavir, lamivudine and either nevirapine (children under 3 years) or efavirenz (children over 3 years), a three medicine combination recommended by the World Health Organisation (WHO) guidelines. The first group contains just this treatment regimen for the entire trial. The other two groups both have a fourth anti-HIV drug, zidovudine for the first 36 weeks. After 36 weeks, one of these groups drops zidovudine and the other drops either nevirapine or efavirenz depending on which drug they are taking. This is detailed further in the trial schema.
