What Drugs Lower High Cortisol Levels?
Corrtisol, as defined by the National Institutes of Health, “is a steroid hormone released from the adrenal gland in response to ACTH, a hormone from the pituitary gland in the brain.” Cortisol levels naturally increase during emotional or physical stress, but chronically elevated levels of the hormone causes chronic stress and memory problems, and may also cause brain cell damage. Also, elevated cortisol levels may indicate Cushing’s disease or tumors on the adrenal gland. Fortunately, research has shown promising results on the pharmacological reduction of cortisol levels and/or its effects. Steroidogenesis Inhibitors Drugs, such as ketoconazole, mitotane and trilostane result in the complete or partial inhibition of cortisol synthesis. Ketoconazole, for example, is believed to act directly on the secretion of ACTH in Cushing’s patients and has shown a reduction of cortisol levels in their urine and plasma. According to a report in “Medscape Today,” combinations of these drugs may cr
