What doses of cholesterol have been used to treat SLOS?
Doses have varied from 50-150 mg cholesterol per kilogram (Kg) of body weight per day. For a 70 Kg adult with SLOS this would be a dose between 3500 mg to10,500 mg per day. The lower adult dose would be approximately equivalent to eating 14 eggs or 14 egg yolks (the yolk contains most of the cholesterol) a day. The lower dose appears to be as effective as the higher doses and thus, the lower dose is the most recommended dose for SLOS.
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