What dosage of injectable or oral estradiol would likely produce normal female blood levels?
Regarding injections: Futterweit achieved estradiol blood levels of ~900 pg/ml with 40-80 mg injectable estradiol valerate monthly, combined with 0.1 – 0.5 mg oral ethinyl estradiol. This blood level is about twice the maximum normal female mid-cycle peak. A monthly dose of 40 mg of injectable estradiol valerate alone might be a good starting point. See: Testicular steroidogenic response to human chorionic gonadotropin of fifteen male transsexuals on chronic estrogen treatment elsewhere at this site. Regarding oral estradiol, Goh reported average estradiol levels of 145 pg/ml (range 88 – 211 pg/ml) in 9 non-castrated MTF transsexuals who received oral estradiol 4 mg per day for three months. This is about one-third of the maximum normal female mid-cycle peak. This dose might be a reasonable starting point. However, please be aware that with any particular dose of oral estrogen, the blood level achieved will vary considerably from person to person. See: The feminization of gonadotropin
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