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• TRICYCLIC ANTIDEPRESSANT (noun) The noun TRICYCLIC ANTIDEPRESSANT has 1 sense: 1. an antidepressant drug that acts by blocking the reuptake of norepinephrine and serotonin and thus making more of those substances available to act on receptors in the brain Familiarity information: TRICYCLIC ANTIDEPRESSANT used as a noun is very rare.
