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What does the Y chromosome SRY do?

April 26, 2017CHROMOSOME sry

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What does the Y chromosome SRY do?

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SRY, Sex related Region on the Y chromosome, encodes a transcription factor that is expressed in the testis support cells, sertoli cells, in the developing male gonad and leads to gonad and genital differentiation and has several effects. Sertoli cells then: • induce germ cells to commit to sperm cell development • express anti-Mllerian hormone which causes the Mllerian duct (= paramesonephric duct) to regress • induce Leydig cell differentiation, which then secrete testosterone (See Molecular Biology of the Cell – Influence of Sry on gonad development.