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What does the MPCA suggest for the estimation of potential human health risks using Central Tendency Values for human exposure factors, and when is this estimation useful?

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What does the MPCA suggest for the estimation of potential human health risks using Central Tendency Values for human exposure factors, and when is this estimation useful?

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An important element of a human health risk assessment is the transparent communication of uncertainty and variability. A portion of the uncertainty in a final risk estimate stems directly from the assumptions used to characterize potential human exposures. The USEPA and MPCA recommend estimating risks based on a set of default exposure assumptions, called the “Reasonable Maximum Exposure” (RME). One approach to communicate the uncertainty associated with the default exposure assumptions is to provide risk estimates using multiple human exposure assumptions. Risk results using central tendency human exposure factors should not replace risk estimates based on the RME and should not be considered a refinement to screening level risk assessments that follow MPCA’s Air Emissions Risk Analysis (AERA) guidance. Including central tendency exposure estimates would generally be appropriate in larger multi-pathway risk assessments, where more discussion of uncertainty is warranted. Information t

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