What does the activated alpha-2-macroglobulin help remove from the blood stream?
In addition to excessive cytokines, activated alpha-2-macroglobulin is able to bind to, and promote the clearance of: various antigens such as bacteria, viruses, yeast, pollens and other allergenic substances. Excessive antibodies, such as those seen in autoimmune disease, can also be removed. Circulating immune complexes – which are formed when antigens and antibodies stick together – can be removed. It is important to note that circulating immune complexes may be quite elevated in autoimmune disease and can cause disease when they become imbedded in tissues. CICs are very pro-inflammatory As I mentioned, enzyme activated alpha-2 macroglobulin facilitates the removed of cellular debris and damaged proteins. These damaged proteins may be the result of increased oxidative stress, or of glycosylation – the damage caused by excessive blood sugar. The enzyme activated alpha-2-macroglobulin also facilitates the removal of other proteins such as excessive fibrin, amyloid and c-reactive prote
