What does spironolactone have to do with treating male pattern baldness?
A. There are three distinct benefits of topical spironolactone in its use as a treatment for MPB. (1). Spironolactone significantly reduces the amount of DHT in the scalp by inhibiting the conversion of precursor steroids to DHT. (2). Spironolactone reduces DHT in the scalp by converting localized testosterone into estrogen, which is thought to be protective of the hair follicles. (3). Spironolactone blocks the follicular androgen receptor sites, thereby rendering any residual or circulating DHT harmless to the hair follicles.
