What Does Rabies Preexposure Prophylaxis Involve?
Preexposure rabies prophylaxis is administered for several reasons. First, although preexposure vaccination does not eliminate the need for additional therapy after a rabies exposure, it simplifies management by eliminating the need for RIG and decreasing the number of doses of vaccine needed — a point of particular importance for persons at high risk for being exposed to rabies in areas where immunizing products might not be available or where lesser quality biologics might be used placing the exposed person at increased risk for adverse events. Second, pre- exposure prophylaxis might protect persons whose postexposure therapy is delayed. Finally, it might provide protection to persons at risk for unapparent exposures to rabies.
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