What does major depressive episode mean?
• MAJOR DEPRESSIVE EPISODE (noun) The noun MAJOR DEPRESSIVE EPISODE has 1 sense: 1. (psychiatry) a state of depression with all the classic symptoms (anhedonia and lethargy and sleep disturbance and despondency and morbid thoughts and feelings of worthlessness and sometimes attempted suicide) but with no known organic dysfunction Familiarity information: MAJOR DEPRESSIVE EPISODE used as a noun is very rare.