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What does it mean if the nuchal translucency(NT) is abnormal?

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What does it mean if the nuchal translucency(NT) is abnormal?

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An increased nuchal translucency can indicate a risk for chromosome defects, such as trisomy 21 or 18, cardiac or other defects. If the nuchal translucency (NT) is significantly thickened, then a detailed ultrasound of the fetal heart and fetal anatomy are recommended between 19 and 22 menstrual weeks.

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