What does histological grade mean?
Ann Ainsworth, M.D.: The grade of a cancer is a measure of how much the tumor looks like the normal tissue from where it originated. A grade 1, or well-differentiated carcinoma, looks very much like the normal, nearby breast tissue. Grade 2, or moderately differentiated carcinoma, looks less like the normal tissue. Grade 3 show very little similarities to the normal breast ducts or lobules. Grade I carcinomas tend to behave better than grade 2 or 3 carcinomas.