Important Notice: Our web hosting provider recently started charging us for additional visits, which was unexpected. In response, we're seeking donations. Depending on the situation, we may explore different monetization options for our Community and Expert Contributors. It's crucial to provide more returns for their expertise and offer more Expert Validated Answers or AI Validated Answers. Learn more about our hosting issue here.

What do smg genes do?

April 26, 2017genes SMG

0

Posted

What do smg genes do?

1 Answer

0

Posted

The normal function of the smg genes is to promote nonsense-mediated decay (NMD) of mRNAs with premature (mutant) stop codons. In a smg- background, these mRNAs which are usually targeted for degradation stick around. If they are actually functional, but are usually (in a smg+ background) degraded and thus null, then these short but wt proteins can “suppress” (really, rescue) the mutant phenotype.