What did we learn on the role of PKC isozymes?
There are over 200 published studies using these regulators that were carried out by our group and independently by other laboratories. Our studies focused mainly on the role of PKC in heart function. Using these peptide regulators of PKC we found: Beta II PKC mediates heart failure. Epsilon PKC activation regulates the activity of the L-type calcium channel and sodium channel and are therefore potential therapeutic target for cardiac arrhythmia (16-18). Epsilon PKC activation reduces damage induced by ischemia both in isolated myocytes and in intact heart. Delta PKC inhibition reduces damage induced by heart attack, stroke and damage to the brain induced by chronic hypertension. The delta PKC inhibitor was also used in human patient with acute myocardial infarction. Epsilon and gamma PKC peptide inhibitors that inhibit pain sensation are currently in human clinical trials. We are also interested in the role of PKC isozymes in breast cancer growth and in the angiogenic response associa
Related Questions
- Will there be an opportunity to meet Amgen Scholars participating in the U.S. Program at other host universities and to learn more about biotechnology and drug discovery and development?
- Can a mage with One-College-Only Magery learn spells with prerequisites outside that college?
- Will St. Louis learn from history?
