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What did the Womens Health Initiative (WHI) reveal about the risks of menopausal hormone therapy (HT)?

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What did the Womens Health Initiative (WHI) reveal about the risks of menopausal hormone therapy (HT)?

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The HT portion of the WHI studied outcomes in postmenopausal women (average age 62) for ~5 years after initiation of conjugated estrogen 0.625 mg + medroxyprogesterone acetate 2.5 mg daily, conjugated estrogen 0.625 mg (for women who had had hysterectomy), or placebo (1,2).

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