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What dictates lentiviral host cell range (tropism)?

April 26, 2017CELL dictates host lentiviral range tropism

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What dictates lentiviral host cell range (tropism)?

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Lentiviral tropism is determined by the ability of the viral envelope protein to interact with receptors at the host cell surface. The VSV-G envelope protein is commonly used in lentiviral particle production because it confers broad tropism over a range of species and cell types.