What criteria does dbSNP use to determine double-hit SNPs independently of Dr. Jim Mullikins algorithm?
I have not made the double-hit, two-allele computation for some time now. Currently, we rely exclusively on Dr. Mullikin’s data AFAIK. As for my double-hit computation, I made the initial calculation of double-hit SNPs based on submitter-supplied clone accessions. If we can establish that two different submitters working with different clone libraries had independently identified each allele, we confirmed the SNP as a double hit. I believe this mined something on the order of 10 K of double-hit SNPs. We also knew that we had a bolus of TSC SNPs mined from traces known to be from sources other than the clone libraries used in the human genome. I’m a bit fuzzy on the details now; I do, however, recall that the individuals supplying the TSC traces were pooled together, but that a statistical argument, based on the number of individuals in the pool, allowed us to consider each trace as an independent sample with high confidence. Additionally, the allele appearing on the genome itself const
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