What could be the effects of a centrosomal oncogenic kinase on centrosome function?
The presence of a constitutively active X-FGFR1 kinase at the centrosome may affect several processes associated with the function of this organelle. More than just an MTOC, the centrosome is important for the regulation of cell cycle progression.68, 69, 70 It also influences cell shape, polarity and motility and is linked to DNA repair.71, 72 Accordingly, many proteins involved in these processes are found at the centrosome, including cyclins, BRCA1, P53, and various kinases, phosphatases, signalling substrates and cell cycle regulators.21, 73 Our recent results indicate that X-FGFR1 at the centrosome deregulates G1/S events, and particularly the restriction point from G1-phase to S-phase, when centrosome duplication occurs.22 Abnormal activation of X-FGFR1 at the centrosome may affect the regulation of various molecular complexes. It may activate a proliferation signal at the centrosome, relieve a brake on the cell cycle, and simultaneously perturbate apoptosis in the targeted stem c
