What constitutes “significant” and “substantial” in determining if an application is new?
This is inevitably a scientific judgment for which no set of universally applicable examples can be provided. However, rewording of the Title and Specific Aims or incorporating minor changes in response to comments of reviewers from the prior review does not constitute substantial changes in scope, direction, or content. Requests for review by a different review committee or funding consideration by a different NIH institute are not sufficient reasons to consider an application as new.
