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What constitutes a significant problem worthy of the application of formal Root Cause Analysis techniques?

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What constitutes a significant problem worthy of the application of formal Root Cause Analysis techniques?

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This is somewhat subjective. A few business examples where a formal Root Cause Analysis should be considered are: 1) any incident involving fatalities or significant injuries; 2) malfunctions in required equipment; 3) problems that may lead to undesirable legal and/or regulatory exposure; and 4) any problem with the potential to significantly affect profitability. (Please note that this is not an exhaustive list.

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