What coagulation parameter is followed to assess the need for fresh frozen plasma replacement?
The two tests used are the Prothrombin Time (PT) and the fibrinogen level. Those centers that use PT feel that the PT must be elevated more than 2 or 3 seconds above the control before FFP should be considered. Since fibrinogen is removed during TPE, other centers will follow fibrinogen levels. They feel that a fibrinogen level of less than 125 mg/dl is an indication for FFP replacement.
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