What chromosome is affected by dwarfism?
There are many different forms of dwarfism, caused by different mutations. Some of tghe most common include: Achondroplasia (the most common form of dwarfism), caused by a mutation in the Fibroblastic Growth Factor Receptor gene 3, on chromosome 4. Spondyloepiphyseal dysplasia congenita is caused by a mutation in the pro-alpha Collagen 1(II) gene on chromosome 12. Diastrophic dysplasia is caused by a mutation in the SLC26A2 gene – a member of the solute carrier family located on chromosome 5. Pseudoachondroplasia is caused by a mutation in COMP (cartilage oligomeric matrix protein) on chromosome 19. Hypochondroplasia, like achondroplasia is caused by a mutation in the FGFR3 gene on chromosome 4. And osteogenesis imperfecta (aka brittle bone disease) is usually caused by a deficiency in Type I collagen, and is also often associated with dwarfism. It can be caused by a number of mutations in different genes on various chromosomes.
